Dr. Kfir Ben Harush
Kfir received his B. Sc and M. Sc in chemical engineering, and Ph. D in Structural biology from Ben-Gurion University. His Ph. D studies was performed with Prof. Ohad Medalia. During that period, Kfir and colleagues decipher the architecture of nuclear lamin filaments assembled in vitro. Kfir was awarded the Lev Margulis Memorial Prize in the field of microscopy for that work. Currently, Kfir lab uses lamin proteins to build nano- to macroscopic biological materials. Overall, the lab seek to answer the following fundamental questions: What are the structural and mechanical properties of lamin proteins assemblies in health and disease? How does a single point mutation alter the architecture and mechanics of hierarchical structures assembled from nuclear lamins? The answer to these questions has broad ramifications, from a fundamental understanding of structure-function in protein materials to cell nucleus mechanics
2010 -2011 Weizmann Institute of Science, Rehovot, Israel
Postdoctoral studies, Department of Biological Chemistry
Project: "Structural characterization of membrane-bound FtsY- ribosome complex of E. coli"
Advisor: Prof. Eitan Bibi
2005 -2010 Ben Gurion University, Be'er Sheva, Israel
Kreitman Graduate School, Ph.D. Program, Department of Life Sciences
Dissertation: "The structure and function of the nuclear lamin filaments"
Advisor: Prof. Ohad Medalia
2003-2005 Ben-Gurion University of the Negev, Israel
Chemical Engineering; M. Sc, August 2005, with distinction
Dissertation: “Catalytic properties of solid alkaline metal
hydroxides in oxidation of 1-phenylethanol to acetophenone”
Advisors: Prof. Moti Herskowitz and Prof. Adi Wolfson
2000-2003 Ben-Gurion University of the Negev, Israel
Chemical Engineering; B. Sc, June 2003, with honor
Intermediate filaments proteins
Structural biology (cryo electron microscopy)
Introduction to chemical engineering I (material balance)
Introduction to chemical engineering II (energy balance)
Introduction to chemical engineering III (separation processes and thermochemistry)
Thermodynamics I (Mechanics)
Thermodynamics II (Solutions)
Fundamentals of heat transfer
Fundamentals of mass transfer
Introduction to statistics and process control
Design and analysis of experiments
Biomimcry and entrepreneurship
Chemical engineers at the Natural Gas Industry
Turgay Y, Eibauer M, Goldman AE, Shimi T, Khayat M, Ben-Harush K, Dubrovsky-Gaupp A, Sapra KT, Goldman RD, Medalia O. (2017) The molecular architecture of lamins in somatic cells. Nature. 543, 261-264.
Zingerman-Koladko I, Khayat M, Harapin J, Shoseyov O, Gruenbaum Y, Salman A, Medalia O, Ben-Harush K (2016) The assembly of C. elegans lamins into macroscopic fibers. J Mech Behav Biomed Mater. 63:35-43.
Bank EM, Ben-Harush K, Feinstein N, Medalia O, Gruenbaum Y. (2012) Structural and physiological phenotypes of disease-linked lamin mutations in C. elegans. J Struct Biol. 177(1):106-12.
Zeytuni N, Ozyamak E, Ben-Harush K, Davidov G, Levin M, Gat Y, Moyal T, Brik A, Komeili A, Zarivach R. (2011) Self-recognition mechanism of MamA, a magnetosome-associated TPR-containing protein, promotes complex assembly. Proc Natl Acad Sci U S A., 108(33): E480-7.
Bank, EM., Ben-Harush, K., Wiesel-Motiuk, N., Barkan, R., Feinstein, N., Lotan, O., Medalia, O., Gruenbaum, Y. (2011) A laminopathic mutation disrupting lamin filament assembly causes disease-like phenotypes in C. elegans. Mol Biol Cell, 22(15), 2716-28.
Ben-Harush, K., Maimon, T., Patla, I., Villa, E. and Medalia, O. (2010) Visualizing cellular processes at the molecular level by cryo-electron tomography. J Cell Sci, 123, 7-12.
Ben-Harush, K., Wiesel, N., Frenkiel-Krispin, D., Moeller, D., Soreq, E., Aebi, U., Herrmann, H., Gruenbaum, Y. and Medalia, O. (2009) The Supramolecular Organization of the C. elegans Nuclear Lamin Filament. J Mol Biol, 386, 1392-1402.
Taimen, P., Pfleghaar, K., Shimi, T., Moller, D., Ben-Harush, K., Erdos, M.R., Adam, S.A., Herrmann, H., Medalia, O., Collins, F.S., Goldman, A.E. and Goldman, R.D. (2009) A progeria mutation reveals functions for lamin A in nuclear assembly, architecture, and chromosome organization. Proc Natl Acad Sci U S A., 106(49): 20788–20793.
Wolfson, A., Ben-Harush, K. and Herskowitz, M. (2009) Aerobic oxidation of benzylic alcohols with solid alkaline metal hydroxides. Kinetics and Catalysis, 51, 63-68.
Ben-Harush, K., Wolfson, A. and Herskowitz, M. (2006) Unexpected performance of solid alkaline metal hydroxides in liquid phase oxidation of 1-phenylethanol. Lett Org Chem, 3, 664-667.